Sathirakul Korbboon (M2), Department of Chemical System Engineering, received SCEJ 91st Annual Meeting Excellent Student Award

On 19th March 2026, Sathirakul Korbboon (M2), Department of Chemical System Engineering, received SCEJ 91st Annual Meeting Excellent Student Award.

SCEJ 91st Annual Meeting Excellent Student Award

This award is given to student poster presenters who are comprehensively evaluated by reviewers from academia, industry, and government on both research quality and presentation. It is granted to students ranked within the top 12% of all student presentations.

About the Awarded Research
In recent years, demand for monoclonal antibodies (mAbs), which are used to treat serious diseases such as cancer and autoimmune disorders, has been growing rapidly. Glycosylation, the addition of sugar chains onto mAb backbones—produces profiles that serve as critical quality attributes affecting efficacy and safety, requiring production to balance productivity with quality. As candidate cell lines increase, efficient early-stage evaluation and process design become critical. Well-plate experiments, typically used for condition screening, offer underutilized potential for early-stage model-driven process design.

Therefore, in this study, we constructed a mathematical model that links CPPs to glycan profiles by efficiently utilizing a small amount of scale-down experiment data. Using this model, we successfully reproduced cell culture dynamics and glycan fractions under various cultivation conditions, enabling the identification of major CPPs, the quantification of trade-offs between productivity and quality, and the determination of model-driven design spaces. These results are expected to contribute to the design of more efficient mAb cultivation processes that account for glycan quality, with the application of this model to scale-up as the next step toward bridging early-stage design and manufacturing.

Future Aspirations and Comments
This research was made possible through the guidance and support of Professor Hirokazu Sugiyama, my fellow laboratory members, and our industrial and academic collaborators. I will take this award as encouragement to further develop my research going forward.