Research Summary

Biomolecular recognition is based on collective and specific non-covalent interactions between discrete biological molecules. Our laboratory seeks to elucidate the molecular mechanisms by which biological molecules obtain high-specificity and affinity from multiple angles using advanced instrumentation, including physical chemistry and computational science. We aim to produce functional molecules with higher performance and better properties, i.e. drug-modalities, to build a solid foundation from which to develop drugs that modulate specific interactions between biomolecules, and ultimately to understand the principles of molecular interactions in our lives, including Integrated Bio-metal Science (IBmS).

Laboratory

http://park.itc.u-tokyo.ac.jp/phys-biochem/

Biography

Mar.1991
Graduated from Department of Industrial Chemistry, School of Engineering, The University of Tokyo (Bachelor course)
Mar.1993
Graduated from Department of Industrial Chemistry, School of Engineering, The University of Tokyo (Master course)　
Jul.1995
Withdrew from Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo (Doctor Course)
Apr.1997
Earned Doctor of Philosophy (Engineering), The University of Tokyo
Arg.1995
Assistant Professor, Department of Biomolecular Engineering, School of Engineering, Tohoku University
Aug.2001
Lecturer, Department of Biomolecular Engineering, School of Engineering, Tohoku University
Oct.2002
Associate Professor, Department of Biomolecular Engineering, School of Engineering, Tohoku University
Mar.2005
Associate Professor, Department of Medical Genome Sciences, Graduate school of Frontier Sciences, The University of Tokyo
May.2010
Professor, Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo
Apr.2013 - present
Professor, Department of Bioengineering, School of Engineering, The University of Tokyo
Professor, Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
Professor, Institute of Medical Science, The University of Tokyo
Apr.2018 - present
Director, Medical Device Development and Regulation Research, School of Engineering, The University of Tokyo
Apr.2019
Assistant to the President, The University of Tokyo
Apr.2020
Assistant Dean, School of Engineering, The University of Tokyo
Apr.2021 - present
Special Advisor to the President, The University of Tokyo
Apr.2023 - present
Vice Dean, School of Engineering, The University of Tokyo

Award History

• 2000 Lecture Award, Division of Biofunctional Chemistry, The chemical Society of Japan
• 2002 Young Investigator Award, The Japanese Biochemical Society
• 2012 JSPS Prize, The Japanese Society for Promotion of Science
• 2015 and 2019, JB Prize, The Japanese Biochemical Society
• 2021, Advanced Technology Award, Sankei Newspaper Inc.

Published Paper

• Structure and role of the linker domain of the iron surface-determinant protein IsdH in heme transportation in Staphylococcus aureus. Valenciano-Bellido S, Caaveiro JMM, Morante K, Sushko T, Nakakido M, Nagatoishi S, Tsumoto K. J Biol Chem, 2022; 298, 101995.
• Molecular basis for the activation of actinoporins by lipids. Caaveiro JMM, Tsumoto K. Methods Enzymology, 2021; 649, 277-306.
• Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors. Yoshimura C, Nagatoishi S, Kuroda D, Kodama Y, Uno T, Kitade M, Chong-Takata K, Oshiumi H, Muraoka H, Yamashita S, Kawai Y, Ohkubo S, Tsumoto K. J Med Chem. 2021; 64, 2669–2677
• Antibody Affinity Maturation by Computational Design. Kuroda D, Tsumoto K. Methods Mol Biol. 2018;1827:15-34.
• Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI. Kiyoshi M, Caaveiro JM, Kawai T, Tashiro S, Ide T, Asaoka Y, Hatayama K, Tsumoto K. Nature Commun. 2015; 6:6866.
• Hyperthin nanochains composed of self-polymerizing protein shackles. Matsunaga R, Yanaka S, Nagatoishi S, Tsumoto K. Nature Commun. 2013;4:2211.
• Role of arginine in protein refolding, solubilization, and purification. Tsumoto K, Umetsu M, Kumagai I, Ejima D, Philo JS, Arakawa T. Biotechnol Prog. 2004 Sep-Oct;20(5):1301-8.