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Xiongjie Jin (Department of Applied Chemistry) won the Best Poster Presentation Award in the 4th Asia-Oceania Conference on Green and Sustainable Chemistry and the 7th GSC Student Travel Grant Award

 

Xiongjie Jin (Department of Applied Chemistry) won the Best Poster Presentation Award in the 4th Asia-Oceania Conference on Green and Sustainable Chemistry and the 7th GSC Student Travel Grant Award.

 

 

<About awarded research>

Cross-coupling reactions are of great importance in the field of organic synthesis. Especially, palladium-catalyzed reactions are among the most widely utilized ones because of their high efficiency and reliability. However, these traditional cross-coupling reactions requires pre-functionalization of substrates, which lead to the deterioration of overall synthetic efficiency and generation of large amounts of wastes. In recent years, cross-dehydrogenative coupling reactions by direct activation of C–H or X–H (X = heteroatom) bonds have attracted much attention due to its higher atom efficiency and more environmentally benign nature compared to the traditional cross-coupling methods. From the environmental point of view, oxidative cross-coupling reactions employing molecular oxygen as a terminal oxidant are among the most promising procedures, because these reactions produce water as a sole byproduct.

  In this study, we have successfully developed (i) Cu(OH)2-catalyzed oxidative cross-coupling of terminal alkynes and amides to ynamides and (ii) Cu(OAc)2-catalyzed oxidative cross-coupling of H-phosphonates and amides to N-acylphosphoramidates. Ynamides and N-acylphosphoramidates are very important compounds and have classically been synthesized by non-green multi-step  procedures which produce large amounts of inorganic and organic wastes. The synthetic procedures developed in this study have the following remarkable features; (i) use of inexpensive and easily available copper salts as catalysts, (ii) no need of pre-functionalization of substrates, and (iii) formation of water as a sole byproduct. In addition, these reactions possess wide substrate scope and provide efficient synthetic methods for the above-mentioned important compounds.

 

<Comments>

I am very honored to receive these award. I would like to give many thanks to the Japan Association for Chemical Innovation (JACI) for the kind financial support, and also to my supervisors Prof. Noritaka Mizuno and Prof. Kazuya Yamaguchi for their valuable comments and suggestions throughout this study. I will continue to do my best in the field of catalyst research.