A "dynamic” nanomedicine was developed for efficient delivery of nucleic acid medicines to sentinel lymph nodes. This targeted delivery served as a checkpoint for cancer metastasis and activates the immune system, helping to suppress cancer metastasis and recurrence. Importantly, precise size adjustment of the nanomedicine (approximately 10 nm) enabled the efficient delivery to sentinel lymph nodes. Also, the precision nanomedicine design was performed by advanced computational modelling.
A dynamic nanomedicine was fabricated from a single molecule of antisense oligonucleotide (ASO) and two molecules of cationic polypeptide, PEG-(Gly-Lys)10, efficiently delivering ASO to the sentinel lymph node for enhanced cancer immunotherapy.
Papers
Journal: Journal of the American Chemical Society
Title: Structurally Dynamic Polyplexes Enhances Sentinel Lymph Node Delivery of Antisense Oligonucleotides to Inhibit Breast Cancer Recurrence and Metastasis
Authors: Chun Yin Jerry Lau, Hiroaki Kinoh, Xueying Liu, Jiayuan Feng, Fadlina Aulia, Kaori Taniwaki, Nan Qiao, Satomi Ogura, Mitsuru Naito, and Kanjiro Miyata
DOI: 10.1021/jacs.5c04234